Assistant Professor of Microbiology and Immunology
University of California, San Francisco
Parker Institute for Cancer Immunotherapy
Helen Diller Comprehensive Cancer Center
Investigator - Chan Zuckerberg Biohub
Dr. Roybal is an Assistant Professor in the Department of Microbiology and Immunology at the University of California, San Francisco. He is a full member of the Parker Institute for Cancer Immunotherapy and an inaugural Chan Zuckerberg Biohub investigator. He received a doctorate in Immunology from the University of Texas Southwestern Medical Center at Dallas in 2013. There he studied the fundamental cellular and biochemical mechanisms that regulate T cell activation at the system-scale using quantitative live cell fluorescent imaging in Christoph Wulfing's laboratory. Dr. Roybal then moved to Wendell Lim's lab at the University of California, San Francisco and the Howard Hughes Medical Institute as a Jane Coffin Childs Memorial Fund Postdoctoral Fellow. There he developed a new class of synthetic receptors called Synthetic Notch receptors that have far-reaching implications for cell therapies for cancer, autoimmunity, and regenerative medicine.
Daniel B. Goodman, Ph.D.
Jane Coffin Childs Postdoctoral Fellow (co-advised w/Jeff Bluestone and Alex Marson)
B.S. Bioengineering/Bioinformatics - University of California, San Diego
Ph.D. Bioinformatics and Integrative Genomics - MIT and Harvard Medical School (Laboratory of George Church)
About me: My work combines computational modeling, DNA synthesis, and multiplex screens to generate and measure targeted libraries of thousands of genetic elements, genes, and genomes. My current research is focused on understanding and manipulating T-cell signaling through the design and testing of of synthetic cell-surface receptors.
Daniel B. Goodman*, Gleb Kuznetsov*, Gabriel T. Filsinger*, Matthieu Landon, Nadin Rohland, John Aach, Marc J. Lajoie, George M. Church. Millstone: software for multiplex microbial genome analysis and engineering. Genome Biology, 18:101, 2017.
Gleb Kuznetsov*, Daniel B. Goodman*, Gabriel T. Filsinger*, Matthieu Landon, Nadin Rohland, John Aach, Marc J. Lajoie, George M. Church. Optimizing complex phenotypes through model-guided multiplex genome engineering. Genome Biology, 18:100, 2017.
Daniel B. Goodman, George M. Church, and Sriram Kosuri. Causes and Effects of N-Terminal Codon Bias in Bacterial Genes. Science, 342(6157):475–479, 2013.
Sriram Kosuri*, Daniel B. Goodman*, Guillaume Cambray, Vivek K. Mutalik, Yuan Gao, Adam P. Arkin, Drew Endy, and George M. Church. Composability of Regulatory Sequences Controlling Transcription and Translation in E. coli. Proceedings of the National Academy of Sciences, 110(34):14024–14029, 2013.
Marc J. Lajoie, Alexis J. Rovner, Daniel B. Goodman, Hans-Rudolf Aerni, Adrian D. Haimovich, Gleb Kuznetsov, Jaron A. Mercer, Harris H. Wang, Peter A. Carr, Joshua A. Mosberg, Nadin Rohland, Peter G. Schultz, Joseph M. Jacobson, Jesse Rinehart, George M. Church, and Farren J. Isaacs. Genomically recoded organisms expand biological functions. Science, 342(6156):357–360, 2013.
Raymond Liu, Ph.D.
B.S. Biology – Stanford University
Postdoctoral Fellow – NIH T32 Training Grant
Ph.D. Biology – California Institute of Technology (Laboratory of David C. Chan)
About me: My previous work has focused on the regulation of cytoskeleton regulators and dynamins, and on the implications of their interactions in human disease. My current research is focused on engineering improved T-cell responses for immunotherapy.
Jill A. Fahrner, Raymond Liu, M. Scott Perry, Jessica Klein, and David C. Chan. A Novel de novo Dominant Negative Mutation in DNM1L Impairs Mitochondrial Fission and Presents as Childhood Epileptic Encephalopathy. Am J Med Genet A, 170(8): 2002–2011, 2016.
Raymond Liu and David C. Chan. The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1. Molecular Biology of the Cell, 26(24):4466-77, 2015.
Raymond Liu, Maria Teresa Abreu-Blanco, Kevin C. Barry, Elena V. Linardopoulou, Gregory E. Osborn, Susan M. Parkhurst. Wash functions downstream of Rho and links linear and branched actin nucleation factors. Development, 136: 2849-2860, 2009.
Raymond Liu, Sarah Woolner, James E. Johndrow, David Metzger, Adriana Flores, Susan M. Parkhurst. Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos. Development,135: 53-63, 2008.
Axel Wittsen, Ph.D.
B.S. Biomedicine – Lund University
Masters in Biomedicine – Lund University (Laboratory of Frank McCormick, UCSF)
Ph.D. Biomedical Sciences - Lund University (Laboratory of Anna K. Andersson)
About me: My graduate research was focused on phenotypic and molecular changes coupled to cooperation between genetic aberrations in acute leukemia. I am now developing novel engineered T cell therapies for enhanced recognition and treatment of solid tumors such as Mesothelioma.
Hyrenius-Wittsten, A., Pilheden, M., Sturesson, H., Hansson, J., Walsh, MP., Song, G., Kazi, JU., Liu, J., Nance, S., Gupta, P., Zhang, J., Rönnstrand, L., Hultquist, A., Downing, JR., Lindkvist-Petersson, K., Järås, M., Gruber, TA., Ma, J., and Anna K. Andersson, AK. De novo activating mutations drive clonal evolution and enhances clonal fitness in KMT2A-rearranged leukemia. ACCEPTED Nature Communications
Hyrenius-Wittsten, A., Sturesson, H., Bidgoli, M., Jonson, T., Ehinger, M., Lilljebjörn, H., Scheding, S. and Andersson, AK. Genomic profiling and directed ex vivo drug analysis of an unclassifiable myelodysplastic/myeloproliferative neoplasm progressing into acute myeloid leukemia. Genes, Chromosomes and Cancer. 2016 Nov 55(11):847-54
Lilljebjörn, H., Henningsson, R., Hyrenius-Wittsten, A., Olsson, L., Orsmark Pietras, C., von Palffy, S., Askmyr, M., Rissler, M., Schrappe, M., Cario, G., M., Castor, A., Pronk, CJ., Behrendtz, M., Mitelman, F., Johansson, B., Paulsson, K., Andersson, AK., Fontes, M. and Fioretos, T. Identification of ETV6-RUNX1-like and DUX4- rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia. Nature Communications 2016 Jun 6;7:11790
Velasco-Hernandez, T., Hyrenius-Wittsten, A., Rehn, M., Bryder, D., Cammenga, J. HIF-α can act as a tumor suppressor gene in murine acute myeloid leukemia. Blood. 2014 Dec 4;124(24):3597-607
Svensson, G., Hyrenius Wittsten, A., Linse, S., Mani, K. The structural role of N-linked glycans on human glypican-1. Biochemistry. 2011 Nov 1;50(43):9377-87
B.S. Microbiology & Immunology 2016 - University of California, Irvine
Staff Research Assistant I
Garrett Montgomery, M.S.
B.S. Biotechnology 2014 - University Tennessee
M.S. Biotechnology 2017 - San Francisco State University
Assistant Specialist III
B.A. Integrative Biology 2014 - University of California, Berkeley
Staff Research Assistant I
Materials Science and Engineering/Bioengineering - University of California, Berkeley